Whenever you begin driving around in a new city, it takes time to get used to the new street names and their twists and turns. The Valley of the Sun is one city that takes only minutes to learn its layout.
It is really very simple. Down the center of Phoenix running north and south is the street called Central. From Central, streets are numbered starting with First Street and then Second Street, continuing on heading toward the east. From Central, avenues are numbered starting with First Avenue and then Second Avenue, continuing on heading toward the west.
Locating where you want to go is much easier, once you learn the numbering of the streets and avenues. Most of the roads are in straight lines, which also make finding your way not as confusing.