Cibola NWR is located 20 miles south of Blythe, CA, in both Arizona and California along the Colorado River. The refuge is noted for the number of waterfowl and sandhill cranes that winter within its boundary.

An average of 16,000 Canada geese, 15,000 ducks and 1000 greater sandhill cranes (about half of the Lower Colorado River Valley Greater Sandhill Crane population) winter at Cibola NWR.

The Refuge includes 12 miles of former river channels that are now considered backwaters and critical habitat for the endangered Yuma clapper rail and razorback sucker. Other backwaters such as Cibola Lake, Three Fingers Lake and Hartmine Marsh provide nesting, feeding and migrational habitat for the bald eagle, osprey, Southwestern willow flycatcher other neotropical migratory birds as well as waterfowl.

The Refuge is also home to a large population of mule deer, coyotes, bobcats and occasionally mountain lions. Major issues on the Refuge include restoration of riparian habitat, rehabilitation of backwater and wetland habitat, moist soil management, and cropland management for migratory waterfowl and greater sandhill cranes.